We processed and compiled all results from scientic reseach on CBD and Cannabis from the past 40 years. In this study from 1975 entitled Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy, the authors Sallan SE, Zinberg NE, Frei E 3d came to the following conclusions:

Major outcomes(s)

for patients completing the study there were 5 complete responses (no vomiting) and 7 partial responses (50% decrease of vomiting) of overall 15 courses.

Abstract

Anecdotal accounts suggested that smoking marihuana decreases the nausea and vomiting associated with cancer chemotherapeutic agents. Oral delta-9-tetrahydrocannabinol was compared with placebo in a controlled, randomized, “double-blind” experiment. All patients were receiving chemotherapeutic drugs known to cause nausea and vomiting of central origin. Each patient was to serve as his own control to determine whether tetrahydrocannabinol had an antiemetic effect. Twenty-two patients entered the study, 20 of whom were evaluable. For all patients an antiemetic effect was observed in 14 of 20 tetrahydrocannabinol courses and in none of 22 placebo courses. For patients completing the study, response occurred in 12 of 15 courses of tetrahydrocannabinol and in none of 14 courses of placebo (P less than 0.001). No patient vomited while experiencing a subjective “high”. Oral tetrahydrocannabinol has antiemetic properties and is significantly better than a placebo in reducting vomiting caused by chemotherapeutic agents.

Medication

Delta-9-THC

Year

1975

Indication

Cancer chemotherapy

Author(s)

Sallan SE, Zinberg NE, Frei E 3d

Journal

New England Journal of Medicine 1975;293(16):795-797

Design

Controlled study

Type of publication

Other


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